6. Edie McClurg
There’s a certain round, fussy, and slightly dense Midwestern thirty-something that seems to appear in most comedies, and when you check the credits, it’s usually Edie McClurg. Her credits include Ferris Bueller’s Day Off, Mad About You and Malcolm in the Middle, and if you know who she is, chances are good that you can hear her slightly nasal upper-Midwest accent right now.